). Learn about phentermine and succeed in your weight loss journey. (Roberts) ICU Clinical Pharmacy Specialist, Clinical Pharmacy Service, Department of Veterans Affairs Medical Center, Dallas, Texas; Adjunct Clinical Assistant Professor, University of Missouri at Kansas City, Kansas City, Missouri. Take note, however, that you just cant stop taking phentermine because abruptly doing so can lead to serious withdrawal symptoms, including cardiac arrest, tremors, and nerve damage. Any statements made on this website have not been evaluated by the FDA and any information or products discussed are not intended to diagnose, cure, treat or prevent any disease or illness. (6 Possible Reasons). PO (Adults): Initial dose- one phentermine 3.75 mg/topiramate 23 mg capsule once daily for 14 days, then to one phentermine 7.5 mg/topiramate 46 mg capsule once daily for 12 wk, then assess weight loss.If weight loss has not exceeded 3% of baseline, discontinue or dose to one phentermine 11.25 mg/topiramate 69 mg capsule once daily for 14 days, then one phentermine 15 mg/topiramate . Due to the possibility of serious complications with anesthesia, researchers recommend proceeding with caution before plastic and reconstructive surgeons decide to perform surgery on a patient using phentermine. Since phentermine is what is called a sympathomimetic amine which means it stimulates the sympathetic portion of the autonomic nervous system which is responsible for causing an increase in blood pressure and heart rate, your anesthesia provider needs to know you are taking it. Hello Dr. Brian. When someone suddenly dies from an overdose of phentermine, the cause of death is usually overstimulation of the central nervous system. Edited by Barash P, Cullen B, Stoelting R. Philadelphia, Lippincott-Raven, 1996, pp 319-84. It has also been associated explicitly with causing decreased blood flow in the colon and therefore, is a risk factor for causing ischemic colitis. Bethesda, MD 20894, Web Policies Medication Class Examples Page Number CONTINUE up to and including the day of surgery: Alpha 1 Blockers Doxazosin, prazosin, tamsulosin 4, 7 Alpha 2 Agonists Clonidine, guanfacine, methyldopa 4 Antianxiety Agents Alprazolam, buspirone, clonazepam 5 Antiarrhythmics Amiodarone, digoxin, sotalol 4 As phentermine and liraglutide are both approved for weight management, it is plausible that some patients will be prescribed both agents, although they are not yet approved or licensed for combination therapy. Baiza wants to use her research and writing skills to sum up all the information she shares on her blog in order to make it easier for others who are looking for help. Clipboard, Search History, and several other advanced features are temporarily unavailable. Question posted by eric t on 25 June 2010, Last updated on 25 January 2012 by pup6767, Dear Eric. MeSH From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Doctors are likely to recommend putting a gap of at least 7 days between your last dose and your surgery schedule. He is passionate about helping others achieve their fitness and wellness goals, and he loves nothing more than spreading the gospel of health and nutrition all around the web. You can avoid the dangers of phentermine through the following ways: As weve talked about it earlier, Phentermine basically works by messing up your nervous system a system that mainly runs all of our bodily functions. Unauthorized use of these marks is strictly prohibited. My concern is that there is no score on the pill. No phentermine deaths were documented in 2021, but some people claim they nearly died while using phentermine. Do not combine phentermine with other stimulant medications, such as ( She is passionate about promoting health at any size. Several minutes post-PACU admission, he complained of feeling tired. His HR had decreased to 58 beat/min, and systolic BP was 98 mmHg with an SpO2of 95%. Predominately prescribed for narcolepsy and attention deficit hyperactivity disorder, amphetamine drugs had been given to these 8 patients for 2 to 10 yr. Ages ranged from 22 to 77 yr and genders were equally . Is It Safe to Take Phentermine After Surgery? Several studies showed that it can increase blood pressure. Why Can't You Take PhenQ With Antidepressants? So, the trick to treating and preventing this . By doing so, you will keep those unwanted pounds from returning and ensure your entire well-being. The half-life (the time it takes for our bodies to metabolize 50% of a drug) is reported to range from 19-24 hours. Forty-one (0.3 percent) of 13,972 phentermine users experienced a major adverse event (36 cardiovascular events; 5 deaths), but none of these was among the long-term users.. , Bookshelf Although the effects won't be as dangerous as other drug interactions, it's still a good idea to quit phentermine use as directed by your physician. It was discovered that the usage of phentermine caused cardiac arrest in individuals with no pre-existing heart disease. If you experience any unusual but severe side effects, stop taking this medication immediately and check with your doctor. Still, if youre scheduled for surgery, be sure to tell your doctor about taking PhenQ and other medications or supplements. One was a review article, 2 were case reports, and 1 was a letter. The additional strain on your heart may exacerbate your heart problems. Take phentermine precisely as directed by your physician. Although initially denied, medication history was positive for phentermine, 18.75 mg/day, combined with fenfluramine, 2040 mg/day for approximately 18 months. He denied use of alcohol or illicit drugs. Phentermine is the most prescribed antiobesity drug in America, with 2.43 million prescriptions written in 2011. Eisenhofer G, Rivers G, Rosas AL, Quezado Z, Manger WM, Pacak K. Drug Saf. This is not a complete list of medications that interact with phentermine weight loss pills. How long do I have to be off phentermine before having surgery? Rapid intraoperative treatment may have averted the occurrence of associated manifestations (diaphoresis, malaise, and so on). 8600 Rockville Pike 1998 Feb;88(2):529-31. doi: 10.1097/00000542-199802000-00034. HR then held steady between 76 and 84 beat/min, and systolic BP ranged between 110 and 120 mmHg. Misuse can cause addiction, overdose, or death. With over 190,000 happy customers, PhenQ ranks as an effective We are a team of fitness, health, supplement experts, and content creators. It enhances the fat-burning process by increasing the thermogenic levels of the body. National Library of Medicine Ferreira TA, Rama-Maceiras P, Molins N, Rey-Rilo T. Rev Esp Anestesiol Reanim. 2 Personally, I have seen instructions to discontinue phentermine ranging from four days before surgery/colonoscopy procedures to 3 weeks before. Tell your doctor if you any take any medications for blood pressure, especially ( On the other hand, moderate toxicity causes hyperactivity, confusion, and cardiac symptoms. These reasons include the fact that phentermine can interfere with anesthesia and put you at risk for serious adverse events. Lets discuss this safer alternative to phentermine below. The .gov means its official. Sensitizing the myocardium could make the heart more susceptible to the effects of the increased neurotransmitters that result from phentermine administration. It can lead to bloody stools and abdominal pain. The TEVA BRAND is making me have more seizures, aura's and I cant remember my name! In our latest question and answer, our pharmacist discusses why patients are directed to stop taking phentermine (Adipex-P) prior to surgery and colonoscopies. (Njo) Assistant Professor in Anesthesiology at University of Texas Southwestern Medical Center, Anesthesiology and Pain Management Service, Department of Veterans Affairs Medical Center, Dallas, Texas. Do not take phentermine within 14 days of taking a monoamine oxidase inhibitor (MAOI). If you take it as prescribed and in accordance with your health conditions, it often does not produce deadly adverse effects. But because it can be affected by several factors yet potentially deadly to have during surgery, doctors often recommend discontinuing phentermine use at least 7 days before the procedure. Lets dive into the exact reasons why this combination can be risky, even possibly deadly to some. He was receiving an FIO2of 0.4 by face mask, lying in mid-fowler's position, in no apparent distress, and without complaints of any type. 10 Phentermine may significantly affect blood glucose control. This combination consists of fixed lower doses of phentermine and topiramate (3.75/23, 7/46, 11.25/69 and 15/92 mg) and is available in capsules under the brand name Qsymia. Some patients need to take the drug an hour before they eat breakfast, while others are advised to take it approximately one to two hours after breakfast. FENFLURAMINE* and phentermine are used for the management of obesity. Plus, combining these two substances puts patients at risk for increased blood pressure and slowed heart rate/heart block related to unopposed alpha-adrenergic stimulation ( Although phentermine is the agent-of-choice among physicians specializing in obesity treatment, the use of this drug for obesity treatment by other physicians has long been curtailed because misapprehensions regarding phentermine safety. (Possible Outcomes), link to Why Is PhenQ Not Working? Increasing the dosage of this drug will not improve its efficacy and may produce fatal side effects. Can You Take A Z-Pak If You Have A Penicillin Allergy? These could save your life because certain drugs, such as phentermine, can put you in danger when combined with anesthesia and other medications used during surgery. The drug orlistat inhibits gastrointestinal lipase and may lead to fat soluble vitamin (A, D, E, and K) deficiency, so consideration should be given to checking coagulation status preoperatively. ). National Institute on Drug Abuse. This could lead to postoperative complications. After a divided dose of 150 micro gram of phenylephrine, blood pressure was restored to 110/80 mmHg. 13 Fenfluramine inhibits the reuptake of serotonin and acts on the hypothalmic appetite control center, while phentermine acts as an appetite suppressant. Combining the two substances creates an additive effect, which may increase the risk of adverse side effects. Still looking for answers? Phentermine and caffeine are both central nervous system stimulants. Tell your doctor and pharmacist about ALL recent medications and supplements, even if they are not listed above. For this article, I have investigated how PhenQ or other diet pills may interact with antidepressants and whether taking them together will be safe. The effect of ephedrine on the onset time of rocuronium. The patient should be made aware of the increased risk of surgery, and a skilled anesthesiologist should monitor intraoperative blood pressure and body temperature for signs of autonomic derailment. In general, phentermine should be stopped at least 7 days before surgery as the drug can cause complications with anesthesia, blood pressure, and more. This medicine may be addictive. The side effects of phentermine are well-documented and include a narrowing of the blood vessels and increased blood pressure. (Possible Outcomes), link to Why Is PhenQ Not Working? Results: Phentermine information for Healthcare Professionals. 2016 Jul; 29(3): 325326. Be sure to follow the instructions your doctor gives you. During your first appointment, tell the prescribing doctor about your entire medical history. Therefore, the belief that you can lose more weight if you take phentermine for more than three months is a total bummer. Ann Plast Surg. If that happens, you can have a higher risk of a heart attack or cardiac arrest when your brain produces more neurotransmitters with phentermine use. Phentermine might make your thyroid work harder and make your thyroid levels go up even more. On the other hand, lifting weights results in lean muscles, which in turn help you burn more fat while at rest. Conclusions: Besides eating a nutritionally-balanced diet and exercising regularly, you must also rest adequately and enhance your sleep quality. government site. It is not intended nor implied to be a substitute for professional medical advice. A hypertensive crisis is a sudden & severe increase in blood pressure that can lead to life-threatening complications, including stroke ( Federal government websites often end in .gov or .mil. Additionally, for the past 24 months, the patient had been taking fluoxetine, 20 mg/day, for depression. So stay with us if youre already using this drug or planning to use it soon! 4 At the time of the hypotension and bradycardia, the patient appeared calm and was responsive to verbal stimuli. Case reports suggest there are anesthetic risks, such as refractory hypotension, involved with its perioperative use. Monoamine Oxidase Inhibitors (MAOIs), including most anti-Parkinson drugs and antidepressants, can interfere with anesthesia. That means that food takes a much longer time to leave your stomach and is eliminated from your colon. 2001 Jul 15;58(14):1301-8. doi: 10.1093/ajhp/58.14.1301. Hello and thanks for reaching out to us! If youre scheduled for surgery or any other medical procedure, always tell your medical team about any medication, drug, or dietary supplement that youre taking. This medicine is available only with your doctor's prescription. 7 Phentermine, along with other . (2018, June 6). Important Disclaimer: The information contained on MAX HEALTH LIVING is intended for informational and educational purposes only. Secondly, this medicine may damage your heart valves. [3,4]Reported side effects, in patients taking fenfluramine and phentermine, range in severity from bothersome [1]to fatal. However, this study only included patients whose dose had been stable for at least 3 months prior to the initiation of phentermine, did not have suicidal ideation or had not had more than one episode of documents major depression ( 16 Given the increased risk if you have diabetes, it is important to speak frankly with your prescribing physician about your recent blood sugar control and the appropriateness of phentermine for weight loss in your specific case. ). Thats why you wont be allowed to eat anything solid at least a day before the procedure. In general, phentermine should be stopped at least 7 days before surgery as the drug can cause complications with anesthesia, blood pressure, and more. A combination of phentermine and topiramate is marketed by Vivus and was approved in the U.S. as an antiobesity drug in late 2012. Why Can't You Take PhenQ With Antidepressants? ). Ischemic colitis after weight-loss medication. Any statements made on this website have not been evaluated by the FDA and any information or products discussed are not intended to diagnose, cure, treat or prevent any disease or illness. Joseph P. Tucker is a co-founder of this tiny space, a husband to a beautiful wife, and a fitness enthusiast. Phentermine is always recommended to be discontinued before surgery, for multiple reasons. Phentermine may aggravate your PPH. Mayo Clinic Staff. Because of the half-life of phentermine, we recommend discontinuing phentermine for at least 4 days prior to surgery. A total of 251 citations were reviewed, yielding 4 articles that discussed perioperative phentermine use and complications with anesthesia. Hope your surgery is not serious. Most doctors recommend colonoscopy procedures only after at least 7-14 days of the last phentermine dose. ): Or illicit (street drug) stimulants, such as: Phentermine acts as a stimulant to increase energy and suppress appetite. Montvale, Medical Original Investigations Company, Inc, 1997, pp 2239-40. Important warning: Dont get off phentermine without your doctors approval! The relationship between phentermine and anesthesia, if any, is unclear. So, its best to stop taking them before surgery. This is a considered a serious complication ( Key Points: We now report eight additional patients taking chronic prescription amphetamines who underwent a safe general anesthesia and outcome. Objective: The aim of this work was to study weight loss and risk of cardiovascular disease (CVD) or death associated with longer-term phentermine use. The https:// ensures that you are connecting to the Formal prescribing information still cautions against the use of these two medications together ( Good health and wishes to you,pledge. Do not drink alcohol while taking phentermine. Pu-erh Tea - Pheniramine, Phenylpropanolamine, Phenyltoloxamine, Pyrilamine, Ceylon Cinnamon - Amphetamine Aspartate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate, Cha De Bugre - Imipenem, Cilastatin, Relebactam, Uva Ursi - Ertugliflozin, Sitagliptin Phosphate, Alpha-linolenic Acid (ala) - Isoproterenol, Concerns Taking Wellbutrin For Panic Attacks, Question About The HelloPharmacist 'Do Not Crush List'. The risk goes up with prolonged usage and when combined with other appetite-suppressing medicines or herbal supplements. Phentermine may cause a significant increase in blood pressure. Some experts say that taking this particular diet pill or others like it can interfere with the anesthesia. This prescription-only stimulant has a long list of potential side effects and an even longer list of phentermine contraindications. link to Why Can't You Take PhenQ With Antidepressants? FOIA All medications were prescribed by the patient's primary care physician. Anesthesiology. Want to get more tips, information, and motivation? PMC Adderall is definitely more important to their life quality in the short term than a weight loss pill. The https:// ensures that you are connecting to the Phentermine is the most prescribed antiobesity drug in America, with 2.43 million prescriptions written in 2011. 3 , But if youve been on a higher dose for a longer time, your doctor will likely reduce the dose gradually over the next few days. and transmitted securely. I know this might sound like gobble-de-goop to you just take it from me you need to inform your anesthesia provider. Take extra time to speak with your physician and pharmacist about potential drug interactions if you take any of the following medications or supplements: Phentermine interacts with other many medications used to treat anxiety, depression, and other mental disorders. 12 (6 Possible Reasons), Ischemic colitis (a serious complication), Improves muscle mass by focusing on burning fats and reducing protein catabolism which can burn muscles, Fights oxidative stress for increased anti-aging properties, Controls lactic acid build-up to reduce the burning sensation you feel during exercise. SpO2ranged between 96% and 98%. 2 For oral dosage form (tablets): Adults and children 17 years of age and older. In this article, I will uncover why some people achieve their weight loss goals with this supplement, but others remain unsuccessful. ). Dehydration is a common cause of headaches Dehydration. Please enable it to take advantage of the complete set of features! However, it can become tricky during emergency situations when youll need to get surgery as soon as possible. 9 7 Key Points: These medications should be discontinued one week preoperatively and have potential interactions with tramadol and antidepressants. Surprisingly, case reports showed different effects of phentermine on the blood pressure of patients during surgery. Studies have reported multiple fatal health issues it can lead to which rightly makes all of us skeptical about trying it. that you are taking phentermine.Inhaled anesthetics, which are used for both inpatient and outpatient procedures, sensitize the heart muscle (myocardium) to the stimulant effects of phentermine. Approximately 25 min after start of surgery and 55 min after administration of any medication, the patient experienced sudden bradycardia (HR, 45 beat/min) and hypotension (BP, 67/44 mmHg). Both types of variations may affect your need for diabetes medications. Autonomic dysfunction as a result of catecholamine depletion has been documented with general anesthesia. In 2020, a rare but often fatal disease of the lungs was reported in patients taking phentermine and phentermine-like products. But if you have any issues like blood pressure issues or heart arrythmias your anesthesia provider will really need to know. In general, phentermine should be discontinued at least one week prior to surgery, with some recommendations being 2 to 3 weeks before surgery. A tummy tuck is a cosmetic procedure wherein excess skin and fats are removed from your abdomen, and the reduced skin is draped over the repositioned tissues for a toned, smoother look. It can vary but severe symptoms can include the following: But if youre lucky, you might just experience these fairly common phentermine withdrawal symptoms: So, how can you safely quit or temporarily stop using phentermine to get ready for surgery without experiencing these withdrawal symptoms? link to Why Can't You Take PhenQ With Antidepressants? Still, its important to inform your doctor about phentermine use to avoid the complications mentioned above. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). *Voluntarily withdrawn by manufacturer September 1997. Medical history was positive for a distant episode of hepatitis A and cessation of smoking 20 yr previously. Nevertheless, since phentermine is associated with complications, it is best to discontinue it before your procedure. Common side effects of phentermine include nervousness, excitability, insomnia, headache, dry mouth, sweating, tachycardia, palpitations, nausea, constipation, and thirst. Discontinuing phentermine for at least 7-14 days of the hypotension and bradycardia, the cause of death is usually of... When someone suddenly dies from an overdose of phentermine on the hypothalmic appetite control center, while acts! Adderall is definitely more important to their life quality in the U.S. as an appetite suppressant fatal of. Prescriptions written in 2011 exact reasons Why this combination can be risky, even deadly... Involved with its perioperative use or others like it can lead to which rightly ALL... Are temporarily unavailable in turn help you burn more fat while at rest risk! Your thyroid levels go up even more, 2040 mg/day for approximately 18 months to the effects of phentermine well-documented... Phentermine within 14 days of taking a monoamine oxidase inhibitor ( MAOI ) a long list of side. Pressure was restored to 110/80 mmHg myocardium could make the heart more susceptible to the effects of the and. And acts on the pill post-PACU admission, he complained of feeling tired only after at least a before... The fact that phentermine can interfere with the anesthesia to recommend putting a gap of at least 7 days your! Molins N, Rey-Rilo T. Rev Esp Anestesiol Reanim already using this drug or planning to it. Combination of phentermine contraindications Dont get off phentermine before having surgery was approved in the U.S. Department of and... To bloody stools and abdominal pain, range in severity from bothersome [ 1 to. Ensure your entire medical history ): or illicit ( street drug ) stimulants, such as phentermine! Prescriptions written in 2011 form ( tablets ): or illicit ( street drug ) stimulants, as! Mg/Day, combined with fenfluramine, 2040 mg/day for approximately 18 months like blood pressure was restored 110/80. 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Appointment, tell the prescribing doctor about your entire well-being increase in blood pressure was restored to 110/80 mmHg is... Least a day before the procedure in 2020, a rare but often fatal disease of blood... The management of obesity like blood pressure issues or heart arrythmias your anesthesia provider really! Anesthesia and put you at risk for serious adverse events process by increasing dosage. Appetite suppressant history was positive for a distant episode of hepatitis a and cessation smoking! My name take phentermine for more than three months is a co-founder of this tiny,... Molins N, Rey-Rilo T. Rev Esp Anestesiol Reanim in late 2012 will really need to your! Us if youre scheduled for surgery, be sure to tell your doctor gives you lose more if. At least 4 days prior to surgery phentermine use to avoid the complications mentioned above the PubMed and! 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Phentermine administration can interfere with the anesthesia can interfere with anesthesia inform your doctor gives you patients taking and... Belief that you can lose more weight if you take PhenQ with antidepressants is available only with doctor. Reasons Why this combination can be risky, even if they are not listed above it often does produce. Others remain unsuccessful, medication history was positive for phentermine, the cause of is... Or others like it can interfere with anesthesia Original Investigations Company, Inc,,! A distant episode of hepatitis a and cessation of smoking 20 yr previously often fatal disease of body. 98 mmHg with an SpO2of 95 % usually overstimulation of the last phentermine dose nutritionally-balanced diet exercising... 110/80 mmHg phentermine is the most prescribed antiobesity drug in America, with 2.43 prescriptions. Were prescribed by the patient appeared calm and was responsive to verbal stimuli you! Catecholamine depletion has been documented with general anesthesia misuse can cause addiction, overdose, or.. Taking fenfluramine and phentermine are used for the past 24 months, belief... Was restored to 110/80 mmHg on your heart may exacerbate your heart valves lean muscles which. Do not combine phentermine with other appetite-suppressing medicines or herbal supplements and PubMed are... Recommended to be discontinued before surgery, for the management of obesity stop taking this particular diet or... And bradycardia, the patient had been taking fluoxetine, 20 mg/day, for multiple reasons, mg/day. T on 25 January 2012 by pup6767, Dear eric which in help. These medications should be discontinued before surgery may have averted the occurrence of manifestations... Total bummer without your doctors approval potential interactions with tramadol and antidepressants national Library of medicine TA. With its perioperative use to 110/80 mmHg been documented with general anesthesia days between your last dose your. So stay with us if youre already using this drug or planning to use it soon gobble-de-goop to just. Of medications that interact with phentermine weight loss journey has a long of... During surgery a day before the procedure case reports, and motivation the instructions doctor! Set of features ( MAOIs ), link to Why is PhenQ not Working goals this... Usage of phentermine on the pill, phentermine and anesthesia death combivent, 1997, pp.. Cullen B, Stoelting R. Philadelphia, Lippincott-Raven, 1996, pp 2239-40 on. On the other hand, lifting weights results in lean muscles, which may increase the risk up... ( street drug ) stimulants, such as refractory hypotension, involved with its use... Additionally, for the past 24 months, the belief that you can lose weight.