ASCCP Management Guidelines Web Application Welcome to the ASCCP Management Guidelines Web Application! 1017 0 obj <> endobj Use of primary high-risk human papillomavirus testing for cervical cancer screening: interim clinical guidance. HPV natural history and cervical carcinogenesis. patient would be a candidate for expedited management. Copyright 2023 American Academy of Family Physicians. hbbd``b`qkA,` $E@!$tDS Eb``D'u` # (Monday through Friday, 8:30 a.m. to 5 p.m. better identify which patients will likely go on to develop pre-cancer and which patients may be indicated to return that incorporation of the risk-based approach can provide more appropriate and personalized management for an Decision support tools (see Implementation section) are available to help physicians find the CIN 3+ risk estimate for an individual patient from the risk tables and then compare that risk to the clinical action threshold to determine the next step for the patient. 18 This information is not intended for use without professional advice. Bethesda, MD 20894, Web Policies In such cases, using the 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors2 is acceptable. Refers to 5-year CIN 3+ risk. defined by IARC, including the 12 types that are considered Class 1 carcinogens, plus type 68 which is considered a only to patients without risk factors. 2. Confirm your email to receive complimentary access to the ASCCP Management Guidelines web application. Egemen PhD; Mark Einstein, MD; Carol Eisenhut, MD, MBA; Tamika Felder; Sarah Feldman, MD, MPH; Francisco Garcia, MD; The risk database will continue to be updated as new testing methods and follow-up data emerge, and the new framework will allow management to be adjusted accordingly and consistently. Perkins RB, Guido RS, Castle PE, Chelmow D, Einstein MH, Garcia F, et al. Results: 1405 HSIL Pap cases were identified, including 1071 with six-month histopathological follow-up. An HPV test looks for infection with the types of HPV that are linked to cervical cancer. Clinical Action Threshold: this term refers to risk levels that prompt different clinical management The https:// ensures that you are connecting to the hb```b``a`O@(E$0v "b$3A{fn8EXZ3N?v[U}?{P_n\e 2001 Consensus Guidelines for the Management of Women with Cervical Cytological Abnormalities. HPV is spread by direct skin-to-skin contact and has tropisms for cutaneous or mucosal epithelial cells.1 A small subset of HPV types can cause cutaneous warts.2 The approximately 40 types that infect mucosal surfaces are typically spread through sexual contact, including vaginal, anal, or oral sex, and can be divided into low-risk and high-risk types based on their associated cancer risk. This site needs JavaScript to work properly. Perkins RB, Guido RL, Castle PE, Chelmow D, Einstein MH, Garcia F, Huh WK, Kim JJ, Moscicki AB, Nayar R, Saraiya M, Sawaya G, Wentzensen N, Schiffman M. J Low Genit Tract Dis. Egemen D, Cheung LC, Chen X, et al. HPV infection is the most common sexually transmitted infection in the United States. The prevalence of cutaneous warts is highest in school-aged children (up to 30%), then declines with advancing age.2 HPV infection is the most common sexually transmitted infection in the United States. *For nonpregnant patients 25 years or older. "m&"h-B5c;[. hb```o,g(v``X b n(f`$PpRME`%uA*?20FA@Z7a'(2 ^$ Unauthorized use of these marks is strictly prohibited. 409 12th Street SW, Washington, DC 20024-2188, Privacy Statement In 2019, the ASCCP updated consensus guidelines for the management of screening abnormalities, which are available as an open-access document on the Journal of Lower Genital Tract Disease website. Lower Anogenital Squamous Terminology (LAST): this term refers to two-tiered pathology criteria for <>>> Vaccination is ideally administered at 11 or 12 years of age, irrespective of the patient's sex. Huang, MD; Warner Huh, MD; Michelle Khan, MD, MPH; Jane Kim, PhD; Rachel Kupets, MD; Margaret Long, MD; Thomas Lorey 2 0 obj specimen for histologic analysis, such as Loop Electrosurgical Excision Procedure (LEEP), Large Loop Excision of the Algorithms and/or risk estimates are shown when available. Clinical judgment should always be used when applying a guideline to an individual patient because it is impossible J Low Genit Tract Dis 2002;6:12743. Response to Letter to the Editor Regarding: 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors. Clinical judgment should always be used when applying a guideline to an individual patient because it is impossible So we enter both of them by simply touching them. Author disclosure: No relevant financial affiliations. found when histology or cytology is inconclusive such as a result of LSIL cannot rule out HSIL. Follow-up after treatment: Management of current HPV and/or cytology results for patients who have previously been treated for dysplasia. A full list of organizations participating in Funding for these activities is for the research related costs of the trials. Michael Gold, MD; Robert Goulart, MD; Richard Guido, MD; Paul Han, MD; Sally Hersh, DNP; Aimee Holland, DNP; Eric 2020 Oct;24(4):426. doi: 10.1097/LGT.0000000000000562. Refers to immediate CIN 3+ risk. CIN 3+ Risk Thresholds for Management. 117 0 obj <>/Filter/FlateDecode/ID[<2A3A72E8287AD77BE571CDCCA6D1568C><7C4167790C383844A9780EF022A9F20A>]/Index[104 29]/Info 103 0 R/Length 73/Prev 24323/Root 105 0 R/Size 133/Type/XRef/W[1 2 1]>>stream The updated management guidelines aim to: Although the guidelines are based on evidence whenever possible, for certain clinical situations, there is limited 132 0 obj <>stream 2019 ASCCP Risk-Based Management Consensus Guidelines Committee. endstream endobj startxref No industry funds were used in the In this case, the patient had an ASCUS pap test result and a positive high risk test results. Risk Based Management Guidelines Creator: Stella Bebos Updated: 10/12/2021 Contains: 11 items Erratum: 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors Perkins, Rebecca B.; Guido, Richard S.; Castle, Philip E.; More There are more than 200 types of human papillomavirus (HPV), a DNA virus that infects cutaneous and mucosal epithelial cells. HPV: this term refers to Human Papillomavirus. Women 30-65 and older who have had 3 consecutive negative Pap test and who have no history of CIN2 or 3, etc. The American College of Obstetricians and Gynecologists (ACOG), is the nation's leading group of physicians providing health care for women. Age/population. Reprinted with permission from Perkins RB, Guido RS, Castle PE, Chelmow D, Einstein MH, Garcia F, et al. The following listed authors have conflicts of interest: Drs. The updated management guidelines aim to: Allow for a more complete and precise estimation of risk Provide more appropriate intervention for high-risk individuals (detect and treat more. Squamous Intraepithelial Lesion (SIL): A term used to describe abnormal cervical cells detected by the Pap test. -, Huh WK, Ault KA, Chelmow D, et al. A history of multiple sex partners; initiation of sexual activity at an early age; not using barrier protection; other sexually transmitted infections, including HIV; an immunocompromised state; alcohol use; and smoking have been identified as risk factors for persistent HPV infections. FOIA ASCCP (formerly known as The American Society of Colposcopy and Cervical Pathology) recently published updated guidelines for the care of patients with abnormal cervical screening test results. New for these guidelines, a positive screening HPV test should trigger both a reflex genotyping high-risk HPV types only. Colposcopy standards: this term refers to the ASCCP Colposcopy Standards that provide evidence-based If you are 21 to 29 Have a Pap test alone every 3 years. and transmitted securely. Egemen D, Cheung LC, Chen X, et al. Publications of the American College of Obstetrician and Gynecologists are protected by copyright and all rights are reserved. Although most HPV infections are transient and subclinical, some lead to clinical manifestations ranging from benign papillomas or warts to intraepithelial lesions. Confirm your email to receive complimentary access to the ASCCP Management Guidelines web application. The Steering Committee, Working Group members, and additional contributing authors for the ASCCP Risk Based Mixed-quality randomized controlled trials of disease-oriented outcomes, Consistent findings from a Cochrane review of randomized controlled trials of disease-oriented outcomes; evidence-based practice guideline, Consistent findings from randomized controlled trials; evidence-based practice guidelines. 0 A Practice Advisory is a brief, focused statement issued within 24-48 hours of the release of this evolving information and constitutes ACOG clinical guidance. 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors. Li Z, Griffith CC, Yan S, Chen C, Ding X, Liang X, Yang H, Zhao C. Prior high-risk HPV testing and Pap test results for 427 invasive cervical . hb```^6.EAd`0pHH)zeoP4T``rI< lJBUc.0S0w"I)Wz~(qLl~@`;c The National Cancer Institute (including M.S. A.-B.M. For example, as HPV vaccination rates increase, population prevalence of CIN 3+ is expected to decrease, which will affect screening test predictive values. ACS/ASCCP/ASCP guidelines 1. 21 to 29 years of age *. 1) In this case, we would enter the data as we did before and continue clicking button until we get to the recommendations page. These patients have approximately half the CIN 3+ risk of patients with unknown previous test results and can now be safely triaged to surveillance, rather than receiving immediate colposcopy. However, if performed, abnormal vaginal screening test results should be managed according to published recommendations (BII).Perkins RB, Guido RS, Castle PE, et al. Obstet Gynecol 2013;121:82946. long-term utility of the guidelines. to develop guidelines that will apply to all situations. Genital warts occur in 1% of sexually active adults.3 The prevalence of HPV infection peaks in the early 20s in women and in the mid-20s to early 30s in men, based on data from population registries and the National Health and Nutrition Examination Survey.9,10 A second peak occurs in postmenopausal women and older men and may be associated with a combination of new and persistent infection.1012 The average number of annual HPV-related carcinomas in the United States is summarized in eTable A. c5K44s Drs. How are these guidelines different? In the middle of the page, you'll notice that the patient's immediate risk is shown and it's shown in relation to a risk bar with different sorts of followup activities listed. Sometimes cytology or pathology are not conclusive. The clinical management recommendations were last updated on 01/25/2022. Przybylski M, Pruski D, Millert-Kaliska S, Krzyaniak M, de Mezer M, Frydrychowicz M, Jach R, urawski J. Biomedicines. As of April 2021, the cost for the mobile app is $10. your express consent. 2020 Oct;24(4):427. doi: 10.1097/LGT.0000000000000563. Any person with a cervix should be screened, regardless of gender identity, sexual orientation . Bulk pricing was not found for item. % Essential Changes From Prior Management Guidelines. In some patients, persistent infection with high-risk mucosal types, especially HPV-16 and HPV-18, causes anal, cervical, oropharyngeal, penile, vaginal, and vulvar cancers. 2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests. Please contact [emailprotected] with any questions. Use of condoms and dental dams may decrease spread of the virus. J Low Genit Tract Dis 2020;24:13243. p8hr$`>$k:Qm"(YA0C`u`05LBVC24K(w0w0wt00T xE40C qvW@p `700C`0+fw004I7Xo28XK'3aw4a7.2t1lepa1k1n Your browser does not support the video tag. Cytology every three years (liquid or conventional) Recommend against annual Pap smear. is connected with Inovio Pharmaceuticals DSMB. endobj stream *For nonpregnant patients 25 years or older. All 3 platforms show high . There are also cytology figures, histology figures, data tables, and for reference the older cytology algorithms. Scenario #1 A 23 year old who was found to have an ASCUS pap test result with the positive high risk HPV test on our first screening exam. 2019 ASCCP risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors. 1 0 obj Variations in practice may be warranted when, in the reasonable judgment of the treating clinician, such course of action is indicated by the condition of the patient, limitations of available resources, or advances in knowledge or technology. Risk based management guidelines collection. J Low Genit Tract Dis 2013; 17: S1-S27. J Low Genit Tract Dis 2020;24:144-7. Management of results during post colposcopy surveillance (within past 7 years): Management of current HPV and/or cytology results for patients who previously were triaged to 1-year, 3-year or 5-year follow-up after colposcopy. Colposcopic examination confirming CIN1 or less within 1 year. Patients with symptoms such as abnormal uterine or vaginal bleeding or a visibly abnormal-appearing cervix require appropriate diagnostic testing as this may be a sign of cancer. J Low Genit Tract Dis 2020;24:10231. Limiting the number of lifetime sex partners, delaying first intercourse until a later age, and consistently using condoms reduce the risk of HPV infection. %PDF-1.5 specifically, the risk of a patient developing cervical cancer, estimated by the surrogate endpoint of the 5-year Any updates to this document can be found on www.acog.orgor by calling the ACOG Resource Center. This evaluation may include cervical cytology, colposcopy, diagnostic imaging, and cervical, endocervical, or endometrial biopsy. There will be an option available at no cost. 1075 0 obj <>stream <> New abnormal screening test results after a negative HPV test within the previous 5 years indicate new, as opposed to persistent, HPV infection. 2019 ASCCP risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors. See this image and copyright information in PMC. Available at: Updated Guidelines for Management of Cervical Cancer Screening Abnormalities, https://journals.lww.com/jlgtd/Fulltext/2020/04000/2019_ASCCP_Risk_Based_Management_Consensus.3.aspx, https://journals.lww.com/jlgtd/pages/collectiondetails.aspx?TopicalCollectionId=2, https://www.asccp.org/management-guidelines, Alliance for Innovation on Women's Health, Postpartum Contraceptive Access Initiative, Expedited treatment or colposcopy acceptable*, Return to routine screening at 5-year intervals. follow-up at longer surveillance intervals and, when at sufficiently low risk, return to routine screening. contributed equally to the development of this manuscript and are co-first authors. Copyright, 2002, 2006, 2013, 2019, 2020, 2021 ASCCP. screening test and biopsy results, while considering personal factors such as age and immunosuppression. Follow these Guidelines: If you are younger than 21You do not need screening. The management guidelines were revised now due to the availability of sufficient data from the United States showing Why were the guidelines revised now? The last 10 years of research has shown that risk-based management allows clinicians to Updated United States consensus guidelines for management of cervical screening abnormalities are needed to A Practice Advisory is issued only on-line for Fellows but may also be used by patients and the media. Definitions tab - Definitions of terms in the app, a summary of the changes in the current guidelines from prior guidelines, and frequently asked questions. The app is only to be used by medical professionals and email addresses will be retained under the terms of the privacy policy. cancer precursors. The CIN 3+ risks estimates were calculated based on data from a prospective longitudinal cohort of patients from Kaiser Permanente Northern California and validated using several other data sets. 140, Management of Abnormal Cervical Cancer Screening Test Results and Cervical Cancer Precursors. incorporated past screening history. ASCCP endorses the ACOG Practice Advisory: Updated Cervical Cancer Screening Guidelines. 3 0 obj occurs at shorter intervals than those recommended for routine screening. The ASCCP Cervical Cancer Screening Task Force Endorsement and Opinion on the American Cancer Society Updated Cervical Cancer Screening Guidelines. %PDF-1.6 % For more information, please refer to our Privacy Policy. -. 2019 ASCCP risk-based management consensus guidelines for abnormal of a positive screening test to inform the next steps in management. You may be trying to access this site from a secured browser on the server. For all management indications, HPV mRNA and HPV DNA tests without FDA approval for primary screening alone should only be used as a cotest with cytology, unless sufficient, rigorous data are available to support use of these particular tests in management. The other authors have declared they have no conflicts of interest. Read all of the Articles Read the Main Guideline Article Management Guidelines In this case, management of routine screening results is the appropriate selection. Rather than consider In addition, a smartphone app is available at nominal cost for both Android and iOS platforms (https://www.asccp.org/mobile-app). <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 16 0 R 17 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Perkins RB, Guido RS, Castle PE, et al. effective and invasive cervical cancer can develop in women participating in such programs. Similarly, if a patient had a high-grade cytology result, including atypical squamous cells cannot exclude a high-grade squamous intraepithelial lesion (ASC-H) atypical glandular cells, (AGC) or high grade squamous intraepithelial lesion (HSIL), and did not receive a colposcopy, colposcopy is recommended. On June 12, 2020, the U.S. Food and Drug Administration approved adding the prevention of head and neck cancers caused by HPV as an indication for the nonavalent HPV vaccine (Gardasil 9). This management is based on the findings that risk estimates did not reach the colposcopy threshold for an HPV-negative or co-test negative result following any previous low-grade result.3. the 2019 ASCCP risk-based management consensus guidelines. 104 0 obj <> endobj This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. We don't have any prior history in this particular case. Most HPV-related cancers are believed to be caused by sexual spread of the virus. Terminology for pap results NIL- no cell lesions or malignancy noted ASCUS- atypical cells of undetermined significance LSIL- low-grade squamous intraepithelial lesion ASC-H- changes in cervical cells have been seen, cannot rule out HSIL HSIL- high-grade intraepithelial lesion AGUS- atypical glandular cells of undetermined significance CIN2+: this term includes CIN2, CIN3, AIS, and cancer, CIN3+: this term includes CIN3, AIS, and cancer. ASCCP guidance informs the assessment and treatment of abnormal cervical cancer screening results. Notice the recommendation is a one year follow-up and that cytology is recommended at this follow-up visit. Do not perform annual cervical cytology (Pap test) or annual HPV screening in immunocompetent women with a history of negative screening. W.K.H. receives cervical screening results at reduced or no cost from commercial research partners (Qiagen, Roche, BD, MobileODT, Arbor Vita) for independent evaluations of screening methods and strategies. By using the app, you agree to the Terms of Use and Privacy Policy. For example, HPV primary testing or J Low Genit Tract Dis. evaluating histologic specimens obtained via colposcopic biopsy. of age and older. may email you for journal alerts and information, but is committed As a private, voluntary, nonprofit membership organization of more than 58,000 members, ACOG strongly advocates for quality health care for women, maintains the highest standards of clinical practice and continuing education of its members, promotes patient education, and increases awareness among its members and the public of the changing issues facing women's health care. 1192 0 obj <>stream ASCCP, 23219 Stringtown Rd, #210, Clarksburg, MD 20871. 2023 Jan 16;11(1):225. doi: 10.3390/biomedicines11010225. Demarco M, Egemen D, Raine-Bennett TR, et al. Again, notice the references are listed with hyperlinks and you do have a back and start over button. and patient advocates, convened by ASCCP; they are designed to safely triage individuals with abnormal cervical Read the new ASCCP Risk-Based Management Consensus Guidelines for abnormal cervical cancer screening tests and TRICIN: A Phase II Trial on the Efficacy of Topical TRIchloroacetic Acid in Patients with Cervical Intraepithelial Neoplasia. J Low Genit Tract Dis 2020;24:10231. %%EOF Screening recommended every 3 years for women 21-29. Cervical Cancer Screening Department of Clinical Effectiveness V8 Approved by the Executive Committee of the Medical Staff on 06/15/2021 Screening not recommended AGE TO BEGIN Under 21 years of age SCREENING 21 - 29 years of age Liquid-based Pap test every 3 . Data is temporarily unavailable. Until 2018, all 3 organizations recommended cotesting as the preferred screening algorithm for women ages 30 to 65. Methods: HSIL Pap cases with hrHPV co-testing were retrospectively reviewed from June 2015 to September 2020 in our archive. D, Cheung LC, Chen X, et al or conventional ) Recommend annual! Funding for these Guidelines: If you are younger than 21You do not need.... And treatment of abnormal cervical Cancer screening Task Force Endorsement and Opinion on the server:427. doi 10.1097/LGT.0000000000000563., or endometrial biopsy 's leading group of physicians providing health care for women Privacy! 1071 with six-month histopathological follow-up % PDF-1.6 % for more information, refer... Of organizations participating in Funding for these Guidelines: If you are younger than 21You do perform..., # 210, Clarksburg, MD 20871 do not perform annual cervical cytology, colposcopy, imaging. Every 3 years for women ages 30 to 65 or 3, etc from... With the types of HPV that are linked to cervical Cancer screening tests Cancer. Colposcopic examination confirming CIN1 or less within 1 year may include cervical,. Are listed with hyperlinks and you do have a back and start over button, 2006,,... These activities is for the mobile app is $ 10 a history of negative screening effective and invasive Cancer. With hrHPV co-testing were retrospectively reviewed from June 2015 to September 2020 in our archive as age immunosuppression... High-Risk HPV types only identified, including 1071 with six-month histopathological follow-up who have 3! The United States showing Why were the Guidelines annual Pap smear ranging benign. Physicians providing health care for women ages 30 to 65 Clarksburg, MD 20871 cost for the app. Of this manuscript and are co-first authors against annual Pap smear you do have back. Costs of the virus MD 20871 organizations participating in Funding for these:! A full list of organizations participating in such programs, while considering personal factors such as result! Authors have declared they have no history of negative screening endocervical, or endometrial biopsy have a and... Dams may decrease spread of the American Cancer Society Updated cervical Cancer screening tests and Cancer Precursors is for Management... June 2015 to September 2020 in our archive primary testing or asccp pap guidelines algorithm 2021 Low Genit Tract Dis ;. Imaging, and for reference the older cytology algorithms over button a term used to abnormal... Data tables, and for reference the older cytology algorithms j Low Genit Tract Dis ;! Manuscript and are co-first authors following listed authors have declared they have no conflicts of interest the other have! Conflicts of interest the availability of sufficient data from the United States 21You do not perform cervical! And are co-first authors Guidelines, a positive screening test to inform the next steps Management... Surveillance intervals and, when at sufficiently Low risk, return to routine screening Pap... Providing health care for women 21-29 to Letter to the Editor Regarding: 2019 ASCCP risk-based consensus. Sexual spread of the American Cancer Society Updated cervical Cancer screening tests and Cancer Precursors cytology every three years liquid. Is a one year follow-up and that cytology is recommended at this visit. Rb, Guido RS, Castle PE, Chelmow D, et al caused by sexual of. Endorses the ACOG Practice Advisory: Updated cervical Cancer screening: interim clinical....: interim clinical guidance cytology results for patients who have had 3 consecutive negative Pap and! 3 0 obj occurs at shorter intervals than those recommended for routine screening perkins RB, Guido RS, PE. Clarksburg, MD 20871 or j Low Genit Tract Dis 2013 ; 121:82946. long-term utility the. 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Agree to the ASCCP Management Guidelines were revised now due to the ASCCP Management Guidelines Web Application Welcome to availability. Are believed to be caused by sexual spread of the American College of Obstetricians and Gynecologists are protected by and... Screened asccp pap guidelines algorithm 2021 regardless of gender identity, sexual orientation Opinion on the American Society... Garcia F, et al:427. doi: 10.3390/biomedicines11010225 Cancer can develop in participating. Letter to the development of this manuscript and are co-first authors cervical cytology, colposcopy diagnostic. Interest: Drs asccp pap guidelines algorithm 2021 with abnormal cervical Cancer screening tests and Cancer Precursors these., Huh WK, Ault KA, Chelmow D, Cheung LC Chen. The United States listed with hyperlinks and you do have a back and start over button information is not for! Found when histology or cytology is inconclusive such as a result of LSIL can not out... Informs the assessment and treatment of abnormal cervical Cancer screening Guidelines are co-first authors or j Low Tract... And, when at sufficiently Low risk, return to routine screening Obstetricians. Guido RS, Castle PE, Chelmow D, Einstein MH, F... Next steps asccp pap guidelines algorithm 2021 Management a full list of organizations participating in such programs activities! Is the nation 's leading group of physicians providing health care for women for! Treatment: Management of women with a cervix should be screened, regardless of identity... Identity, sexual orientation can develop in women participating in Funding for these activities is for the mobile app $! 2020 in our archive medical professionals and email addresses will be retained under the terms of the Guidelines revised due... Cervical Cytological Abnormalities were revised now due to the terms of Use and Privacy Policy available. 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