PLEASE read up! I have a history of IBS and have avoided gluten and used probiotics which has helped my GI tract to return to normal. How long is it safe to use at the full recommended dosage and at what dosage is it safe to use after reaching the normal levels? A few, marked low sodium, will be low in salt, but they are also going to be low in all the good things you need to build bones! Let me know how she is doing, Lara, I was taking 680 strontium citrate, 1130 calcium and 450 magnesium citrate. Heres just one of many medical journal articles discussing the benefits of regular weight bearing exercise on preventing falls: Robitaille Y, Laforest S, Fournier M, et al. Re exercise it should be weight bearing or resistance exercise and daily if possible. However, my confusion now lies in the amount of calcium in the two tablets of AlgaeCal Plus. Assuming that I have improved, what is the suggested dosage for each of these nutrients? What you really want is about another 100 mcg of MK-7 so you could take 2 capsules of the Low Dose K2 formula or 1 capsule of the Advanced Super K. Id check costs and go with whichever one is least expensive. Sylvia. (I realize you have read these papers, but wanted to include a couple of quotes from them for others who may be interested and have not.) Here is a link to a review of the research I very recently wrote for Longevity Medicine Review (its written for physicians, but you will get the gist of it and you may wish to suggest your doctor read it, so she or he will be aware of the latest findings in the peer-reviewed medical literature http://www.lmreview.com/articles/view/Vitamin-K2-Essential-for-Prevention-of-Age-Associated-Chronic-Disease/. I thought this might be in one of the two papers you kindly provided links to, but I could not find anything re thyroid in these, and I have seen nothing suggesting this in any of the papers on natural forms of strontium that I have read. If I end up having dairy foods (like cottage cheese or yogurt or cheese) at lunch, I just take the strontium around 4 pm with a dairy free snack. Wonderful that your bone density is improving! She lectures at medical conferences around the world and is a contributing author to the Textbook of Functional Medicine, the Textbook of Natural Medicine (Osteoporosis chapter, 5th edition, published 2020), and Integrative Therapies for Depression; co-author of The Encyclopedia of Healing Foods, and lead author of Natural Medicine Instructions for Patients; Your Bones: How You Can Prevent Osteoporosis & Have Strong Bones for Life, Naturally, and her latest book, Healthy Bones, Healthy You! Originally, the labels were made just as you suggested, but for some legal reason, they were told 100% is maximum that should be stated for vitamin D. Also as I am sure you know, some experts are still saying 600-800 IU of vitamin D is the recommended amount despite years of research and literally hundreds of studies now showing this is not the case. These natural pills contain pure magnesium, strontium to help max boost absorption rates and open a new chapter so you can continue to grow and restore your . DEXA rescheduled, machine was out of action this morning. If you know where you will be, you could check with health food stores in that area to see which brands they carry, and then I can let you know which of these are being made by reputable, trustworthy companies. Mesenchymal stem cells: Exposure to strontium promotes these precursor cells development into osteoblasts rather than into adipocytes (fat cells) Epub 2011 Oct 21.) Radioactive strontium, which shows up in imaging and is easily traced, is often substituted for calcium in kinetic research because strontium and calcium behave very much alike in the human body. doi: 10.1136/bmjopen-2014-005787. The aim of the strontium ranelate (SR) for treatment of osteoporosis (STRATOS) trial was to investigate the efficacy and safety of different doses of SR, a novel agent in the treatment of postmenopausal osteoporosis. The ability of patients with CKD to clear strontium (and everything else requiring elimination in urine) is compromised. I already had osteoporosis before I started on the drug and this drug is known to cause bone loss so Im happy to have found algae cal plus, but do you have thoughts about whether the strontium is necessary or safe under these circumstances? If you choose to take this medication along with our supplements, there are no separation requirements aside from our general recommendations HERE. [Strontium ranelate: new therapeutic agent for postmenopausal osteoporosis]. Since everyones physiology is unique, its safest to start out with 25 mg and gradually increase up to 50 mg over a couple of months. Of the ten volunteers, nine had osteopenia and/or osteoporosis. Both strontium and citrate are natural substances that are highly beneficial to and are utilized within the body ideally, the majority of the strontium in strontium citrate supplements is absorbed into bone, increasing bone mass and strength. This being said we must ALWAYS trust our own bodies when our personal results dont match up with the research no matter how august and respected the medical journals or how many studies have been published showing something that our own unique body is not agreeing with! I feel this is safe unless a person is on an older anticoagulant medication in which case you must consult with your doctor to help you manage your drug dose so you can gradually increase your vit K without disturbing your INR because studies have been done showing that even much higher doses of MK-7 (over 800 mcg/day) not only caused no adverse effects but resulted in higher levels of activated osteocalcin. This is what I began doing for myself several years ago now after I read and reported in this post on AlgaeCal.com that a half-dose was effective for maintenance. As always, grateful to you! Hi Sara, In fact, in the one and only study on PubMed I could find suggesing even a remote connection between estrogen and strontium a rat study involving ovariectomized rats (an animal model for human postmenopausal women) that were given estrogen, the rats metabolism of strontium normalized. The bottom line is: Strontium citrate improves healthy bone mineralization and resistance to fracture. Strontium ranelate was used in these trials. Strontium does not cause hair loss, so we need to look elsewhere to determine why that is occurring. Presently I take 680 mg stontium citrate daily and 2 algae cal plus twice daily. Thus, I am unable to read the paper in which 170 mg of strontium is said to be more effective, so I do not know what was done and cannot give you more helpful feedback on this. AlgaeCal has 2 in vitro and 2 human clinical trials proving its effectiveness. Night-time (Anti Aging Protocol) The anti-aging protocol is comprised of ingesting 10 grams of elemental l-arginine only at bedtime on a totally empty stomach, which accesses the delta sleep cycle. Citrate is typically good for you; however, when you are infected with Clostridia, it feeds off of citrate, which is why you may experience symptoms like the ones you mentioned. Strontium citrate, however, has never been found to cause this or any of the other ADRs produced by strontium ranelate. Regardless,, however, I urge you to NOT EAT GLUTEN-CONTAINING GRAINS! Hi Linda, Yes, I do think strontium citrate may be of significant help to postmenopausal women with low bone density. I have been taking the 3 capsules at bedtime (2230 mg) which is recommended on the bottle but I also take medications for hypothyroidism. when they have 1000 IUs and 800 IUs respectively? Is there a toxic level for K2 (MK7)? Lara. Strontium Ranelate has a long list of adverse side-effects, starting with common ones like: And less common, but possibly deadly effects like: Overall, the likelihood that you will be among the ones affected may be small although a review of the research on strontium ranelate published in 2005 states Strontium [ranelate] caused a 50% increase in the risk of venous thromboembolism (including pulmonary embolism).. Click on any of the subcategories below to jump to that section: Strontium is a mineral from the earth that is naturally found in your body in small amounts. Thanks for reaching out, Sharon! Can you give me some advice as to the best course I can take to prevent another fracture. Actually, the K1 will have no impact on Gla protein activation it will be used for clotting factors and also has anti-inflammatory effects (so good to help prevent excessive activation of osteoclasts, which is triggered by chronic inflammation). D3 and K2 must be in balance. You can, however, run another type of test that will show you whether you are continuing to lose bone every month until your results show you are no longer losing bone and are stable. I hope this answers your question and inspires you to try AlgaeCal, which significantly improved my bone density in only 10 months, so I can vouch for it personally, and this is why I am doing what I can to help get the word out about AlgaeCal. Thank you. If you have a copy of Your Bones, please check the section on calcium where I have provided a table showing the best food sources of calcium (p. 207 in the book) along with how much calcium is present in a typical serving of each food. I also often add a handful of organic nuts (walnuts, pumpkin seeds, pine nuts, almonds, cashews, pecansetc.) After reading some comments about citrates, some years ago I too Calcium Citrate and ended up with awful heart palpitations and thumping (the only way I know to describe it). Large doses of vitamin C, zinc, and iron, in particular, can upset an empty . When a combined amino acid compound has been introduced to your NAC arrangement, please also consume it when your stomach is empty, just at another moment of the day than the NAC plan. I have a lot less coughing for no apparent reason. Modern wheat has been greatly hybridized over the last 50 years and contains WAY more gluten (gliaden) than wheat used to, and the food industry now also deanimates wheat to make it water-soluble, and thus easier to use in producing products. Hope this helps. Granted it refers to individuals with preexisting conditions, but still. Not only are there no contraindications between the aromatase inhibitors and any of the minerals or vitamins in AlgaeCal Plus and Strontium Boost or the omega-3 fatty acids, curcumin and astaxanthin in Triple Power, but each of these nutritional supplements will help lessen the bone loss! The reason for this is that the EPA/DHA in Triple Power will gradually replace the pro-inflammatory omega-6 (arachidonic acid) in your cell membranes, and specifically in your joint capsule, so your inflammation level will drop and your joint will be able to begin to repair. Strontium supplements should be taken at a different time of day from calcium, or else little, if any, strontium will be absorbed. I have been breaking out in several small red itchy bumps all over my body and my skin feels chapped, including my eye lids. I dont eat dairy or Night Shade vegetables (Im on an anti-inflammatory diet which has helped both the beginnings of arthritis and COPD diagnoses about 4-5 years ago). Because strontium is almost twice as large as calcium, even this tiny number of strontium-for-calcium ions exchanged in your bones can impact DXA readings. The fact that strontium ranelate may cause venous thromboembolism and DRESS syndrome (among other nasty effects) strongly suggests otherwise. I take a Progessive MultiVitamin for women over 50 three times a day as suggested. Her BMD has continually increased, and after 800 days (the most recent check before the paper was submitted to Bone) strontium retention at her finger and ankle were 7 and 15 times higher than the initial baseline reading. This is a pristine environment, and AlgaeCal does everything possible to keep it that way. I explain all this in detail in Your Bones, 2nd edition, pp. But if it does, it shows that estrogen helps us metabolize strontium at a normal, healthy rate. Yes, you will benefit from just AlgaeCal Plus (which will provide you with much more than calcium! If this does not help, you should see your doctor to rule out other causes of gastritis (stomach inflammation), such as H. pylori infection or problems with your gallbladder or pancreas both of which are involved in digestion (the gallbladder secretes bile, pancreas produces pancreatic enzymes), so their dysfunction can cause nausea. So to me you are like an angel. In this study, 176 women over 40 years of age followed one of three different bone-health programs: Plan 1 used a bone-health supplement with vitamin D3 (800 IU), AlgaeCals plant-sourced form of calcium (720 mg), and vitamin K as MK-4 (1.5 mg) for one year. The only issues with strontium citrate (or any form of strontium) are that to err on the side of safety, you should be consuming twice as much calcium (from both diet and supplements) as strontium AND you should take your strontium supplement several hours before or after consuming calcium. I take a 1000 mcg. Trabecular bone is much more metabolically active than cortical bone, so when strontium treatment is stopped, the small number of strontium ions that were exchanged for calcium ions are soon released during normal healthy bone renewal, and this results in a rapid decrease in total bone strontium levels. Also still taking the Metagenics Ostera, as it is supposed to help if you take steroids. Magnesium (as Phosphate) 21mg But, once again, I have no idea of the amount of additional calcium that is entering my body. Find out today why so many people trust us to provide their Classroom Furniture, Canteen Furniture, Conference Room Chairs, Contract Furniture, Office Furniture, Office Desks, Office Chairs, Reception Chairs, Exam Desks, Postura Chairs, School Furniture, Titan One Piece Chairs, Cafe Chairs, Whiteboards and more.. Place an order with us today and have your furniture delivered directly to your door. This would avoid any competition and promote optimal bone benefit from strontium. I actually enjoy eating natto this way and look forward to it. I just noticed the warning on the label . I believe it is a foundational health supplement for everyone not only postmenopausal women. In the research on postmenopausal women, the amount of strontium shown to be effective in helping to increase BMD is 680 milligrams per day. Is a direct quotation from Lis thesis paper cited above on page 41 of the document or page 59 in the PDF format, if you just scroll down to page 41 or type in page 59 or search more effective than you will find it. Estrogen exerts many anti-inflammatory effects, so as we produce less estrogen, our inflammatory potential goes up. Specifically based on strontium levels and safety. By 120 h, the increase was statistically significant at 0.68 0.07 and 0.93 0.05, respectively. Or is there some issue with her ability to absorb calcium as well? Epub 2016 Oct 21. Copyright 2012 Elsevier Inc. All rights reserved. Just be sure the food does not contain calcium. Thanks again for your reply. I am constantly on the lookout for additional information regarding strontium citrate. PMID: It is NOT just calcium, but calcium within the matrix of all the trace minerals required by the sea algae to build its bony structure. https://www.facebook.com/lara.pizzorno.5/videos/10222810189713777/, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070980 Same rationale: BMD is considered by some to be a marker for lifetime estrogen exposure [3]. Although strontium levels in bone do continue to increase over time, the number of strontium ions incorporated into the bone matrix is so miniscule remember one strontium ion replaces less than one calcium ion out of ten, plus as bone remodeling is continuous, these strontium ions are resorbed (just as calcium ions are during normal bone remodeling), so for all practical purposes, strontium intake can be continued throughout life. J Inorg Biochem. I have a smoothie for breakfast that contains a bunch of kale. You just need to take it at a different time of day from when you take calcium (as I have written in the blog and in response to questions here, calcium and strontium compete for absorption, and calcium is better absorbed, so if you take them at the same time, you will receive less benefit from the strontium.) My understanding is that a key reason high impact exercise is beneficial is that it engenders the production of signals that tell bone to build, and these signaling mechanisms do not require long bouts of exercise for activation. Please feel free to contact our Bone Health Consultants 7 days a week at 1-800-820-0184 (USA & Canada, toll-free) or email [emailprotected] for more information and personalized support! Epub 2016 Oct 21. I have never seen anything suggesting strontium causes hair loss. Personally, I had stopped taking Strontium Boost a couple of years ago because my bones are in such good shape now, at age almost 69, that I didnt think I needed the extra help. I have been trying to take the Strontium Boost but it gives me headaches. Please just try these suggestions for 1 week you are very likely to not only see your skin issues resolve but to feel more vital overall. Our correspondence has been a total delight for me. I will look into recommendations for a good endocrinologist in Phoenix. In those with osteoporosis or osteopenia, I would suggest 6 months to a year at the 680 mg dose, then once benefit has been verified with DXA, discussing with their physician the possibility of lowering the dose and rechecking in 6 8 months. Whether this animal study even relates to us humans is highly questionable. I am surprised that Meuiner didnt get back to mehis actual email address is different than the one given in the articles, in fact the one given doesnt even work, luckily I found his actual contact info. I take at night on an empty stomach & within a short amount of time I have very loose stools. Quick follow-up questions. Patients were randomized to receive placebo, 0.5 g, 1 g, or 2 g SR/d for 2 yr. Two women had to suspend training for a few weeks due to knee arthroplasty, six women due to neurological or cardiovascular problems and six women due to glaucoma surgery. Take it with water, and don't eat or drink anything else for at least 30 minutes afterward. Re being insurance poor I am hoping that Dr. Grout will still be able to be helpful. Following is my reply to your questions asking for 1) the exact amount of strontium that ends up as cortical bone and its incidence in making it weaker 2) to view the studies highlighting the assimilation of Strontium as trabecular bone. All 3 forms of vitamin K are beneficial K1, which you can get in abundance from green leafy vegetables, is highly anti-inflammatory as well as being required for normal blood clotting, so you dont bleed to death from even a tiny cut. Compared to the most conservative estimate for annual bone loss given above, AlgaeCal 1 had a positive mean annualized percent change (MAPC) in BMD of a gain of +1.15%. Really when I dropped this message at your blog I did not even have 1% hope that someone would reply me in reality, since morning I am smiling feeling good about my health and sharing this fantastic story of a long distance medical help to everyone at office and family. Calcium is critical for maintaining acid/alkaline balance (called pH) in the blood. Also avoid fast foods and most restaurant foods these are typically loaded with sodium chloride. Heres the math on this: 1.04% x .915 (100%-8.5% = 91.5) = an increase in BMD of 0.95. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosisa 2-year randomized placebo controlled trial. I love both, and try to have an ounce regularly great for a snack with an apple, in omelets, and my familys all time favorite wonderful in tuna melts (I make tuna fish salad with canned tuna, omega-3 rich mayonnaise, lemon juice and a tablespoon of capers or jalapenos, spread it on whole wheat bread, top with a slice of Jarlsberg, spray the top of the sandwich with an organic olive oil version of PAM, put it on a cookie sheet and toast it the oven at 350 degrees for about 20 minutes. What about the AlgaeCal Plus? Thank you Lara for that thorough response! Finally, plasma total ALP activity and IGF-I were also increased in treated animals, compatible with a bone-forming activity of strontium ranelate. Still take at least 5 drops a day. AlgaeCal 2 had a positive MAPC of +2.79%. In other words, your DXA BMD score is, in fact, an estimate its a very good estimate, but it is not 100% an accurate number in the way you are using this adjective. Its a very nice material to read and to know, thank you very much. Kind regards Epub 2011 Jan 11.) I know that I am my own best advocate when it comes to my health and appreciate your willingness to help those of us who are trying to educate ourselves. Could this be a related side effect? While the human skeleton is composed of approximately 80% cortical and 20% trabecular bone, it has been observed that Sr absorption is different between these two types of bone, with trabecular bone showing a higher Sr concentration than cortical bone, likely due to the fact that cortical bone has a slower turnover rate compared to trabecular bone. In contrast, as I stated in the above blog (and backed up with studies conducted over the last 100 yearsthe citations for which are provided in the references) , the natural form of strontium available as a supplement, strontium citrate, has never been shown to produce any of the side effects seen with strontium ranelate. If not, is there anything else that might be contributing to it that you could change to lessen inflammation? No adverse effects. A few other things to keep in mind regarding strontium and calcium: https://www.ncbi.nlm.nih.gov/pubmed/?term=11336927. These areas include our bones (specifically our osteoblasts and chondrocytes in bone), also adipose tissue, the lining of our blood vessels (called the vascular endothelium), the smooth muscle cells in the aorta (the main artery of the body), and numerous sites in the brain. It would be nice to just swallow one pill that would help bones and all else! If so, then I think your plan is excellent. Most water-soluble vitamins can be taken on an empty stomach if you can tolerate it. Do you take a multivitamin as well? A randomized, multicenter, double-blind, placebo-controlled trial was undertaken in 353 osteoporotic women with at least one previous vertebral fracture and a lumbar T-score <-2.4. It is extremely effective truly close to miraculous in its healing effects. Bottom line you can get plenty of calcium cow-free! Vit D3 increases your bodys production of vit K dependent proteins, so you will make more of them and will need more K2 to activate them. I feel more prepared to defend my decision to take strontium boostI was concerned reading about potential heart risks and hearing doctors didnt recommend Strontium (including my friends doctor) but it seems this is misinformation and related to strontium ranelate. She had a Kidney Stone. I was told that I need an operation for this (I am having a slip disc as well (L4 and L5 with sciatica) and too scared to undergo for an operation. Raw vegetables This one is specially for those who are diet conscious and believe that salads are great anytime of the day. Strontium may also interfere with calcium absorption, which is why people taking strontium are advised to take it away from calcium. I was put on several new medications for the heart disease (blood thinner, beta blocker, aspirin, statin, and blood pressure!) Dr. said to increase VitD another 100o and I did. That means I am getting 250 mg of calcium. Firstly sincere thanks and appreciation for the contents of this blog. MATERIALS AND METHODS: The intestinal permeabilities of 14 drugs and three drug-like compounds with different absorption mechanisms in rat and human jejunum were determined by in situ intestinal perfusion. Hi Tyler, I, personally, use AlgaeCals strontium supplement; I know AlgaeCal has the highest standards for its supplements purity and potency, but other companies here also offer strontium citrate. For most everyone, citrate is REALLY good for us its metabolized in the body as an alkalinizing agent in other words, it promotes an alkaline pH inside our cells. Bone resorption (medspeak for bone breakdown) tests measure the amount of certain bone proteins in the urine or blood (serum) that have been released from bone as a result of osteoclast activity. I agree with your assumptions on thyroid and iodinegreat article by the way, I hope others reading these posts will check it outI felt the same way, but I wanted to ask you because I could see that you had already done an extensive amount of research and willing to answer peoples questions/concerns. Strontium ranelate the prescription drug form of strontium is associated with a very serious rash-like syndrome called DRESS syndrome, so if you were taking that, I would be telling you to head to the emergency room right away!. Hope this helps! The PubMed research indicates just the opposite is true. Minor bone loss starts at age 40, increasing to 0.5% to 0.9% a year in peri-menopausal women and to above 1% after menopause, after which the yearly loss in BMD remains about 1%. The only form of strontium for which ADRs have ever been reported is the unnatural, drug form, strontium ranelate, which has never been approved for use in the U.S. and whose use is now severely restricted in Europe. There are many reasons to do so in addition to just being able to take your Strontium Boost unfriendly critters in the digestive tract promote inflammation and interfere with nutrient absorption, and both of those promote bone loss. Please clear this up and let us know whether taking the two minerals separately just allows both to remineralize bones, or causes strontium to replace the calcium in bones. What do you recommend for me age 74 with fine bonesand osteoporosis with the above BMD results? postmenopausal? The research conducted in the above papers used strontium ranelate, however, other papers show the same findings using natural forms of strontium, e.g. No toxicity has ever been shown for K2 (MK-7) at any dose used even in studies in which subjects took more than 800 mcg/day. Hi Carol, Were so sorry to hear that you have been experiencing abdominal discomfort, bloating, and cramping this certainly could be due to the citrate if you have an infection with any species of the pathogenic bacteria Clostridia. PMID: 27684387. Lastly, regarding strontium citrate it has been shown in MANY studies, thousands of women, to be safe and effective. I take warfarin blood thinner and metoprolol beta blocker. have soya yogurts [ Ive suffered from 1/2 hourly hot flushes for 5 years]. I am active and healthy otherwise, on no other medication. I think this is good advice especially if the patient has impaired renal function and thus subsequent decrease in its clearance by the kidney. In the most recently published studies in which the effects of natural strontium salts on bone health were researched, strontium citrate was effectively absorbed and deposited in bone at both a 340 mg per day and a 680 mg per day dose. Thank you. Sources. I take 3 grams of Sodium chloride each day. The range that it should be was given as less than 61. I would be interested to learn of any further research on Lactoferrin and its positive effects on bone building. Here is a link to their main website: http://www.cancercenter.com/?source=GOOGLEBR&channel=paid%20search&c=paid%20search:Google:Google%20-%20National%20Branded:Branded+Test:cancer+treatment+centers+of+america:Exact&OVMTC=Exact&site=&creative=1144020265&OVKEY=cancer%20treatment%20centers%20of%20america&url_id=129386665&adpos=1t1&gclid=CImHytX1iLUCFexxQgodlngA4g AND another link to their contact page: http://www.cancercenter.com/contact-us.cfm. 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To increase VitD another 100o and i did and appreciation for the contents of this blog advice as to best! Calcium absorption, which is why people taking strontium are advised to take it with water and! Keep in mind regarding strontium and calcium: https: //www.ncbi.nlm.nih.gov/pubmed/ why take strontium on empty stomach term=11336927 everyone not only postmenopausal women low. And to know, thank you very much tract to return to normal the that. Extremely effective truly close to miraculous in its clearance by the kidney and promote optimal bone benefit from strontium 74! Keep in mind regarding strontium and calcium: https: //www.ncbi.nlm.nih.gov/pubmed/? term=11336927 is. Yes, i was taking 680 strontium citrate sincere thanks and appreciation for contents... Chloride each day & within a short amount of time i have improved, what is the dosage. In detail in Your Bones, 2nd edition, pp Bones, 2nd edition pp... Read and to know, thank you very much thank you very much humans is highly.. 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Never seen anything suggesting strontium causes hair loss any of the ten volunteers nine... Metabolize strontium at a normal, healthy rate for me age 74 with fine bonesand osteoporosis the...